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KMID : 0525720090140020091
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Journal of Chitin and Chitosan
2009 Volume.14 No. 2 p.91 ~ p.95
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Effects of High Molecular Weight Chitosan on Neonatal Streptozotocin (STZ)-induced Noninsulin-dependent Diabetes Mellitus ICR Mice
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Eo Kyung-Yeon
Kwon Oh-Deog
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Abstract
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The effect of high molecular weight (HMW, 200,000?300,000) chitosan on neonatal streptozotocin (STZ)-induced noninsulindependent diabetes mellitus ICR mice was investigated by analyzing body weight, food and water consumption, urine volume, non-fasting serum glucose, urine glucose, serum triglyceride, and cholesterol levels. HMW chitosan (0.2% or 0.8%) was given to the mice as drinking water for 8 weeks, and daily administration reduced body weight, water consumption, urine volume, serum triglyceride and cholesterol levels; however, HMW chitosan had no effect on blood and urine glucose levels in these mice.
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KEYWORD
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diabetes, high molecular weight chitosan, streptozotocin, mice
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